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Abstract There are few observed high-mass X-ray binaries (HMXBs) that harbor massive black holes (BHs), and none are likely to result in a binary black hole (BBH) that merges within a Hubble time; however, we know that massive merging BBHs exist from gravitational-wave (GW) observations. We investigate the role that X-ray and GW observational selection effects play in determining the properties of their respective detected binary populations. We find that, as a result of selection effects, detectable HMXBs and detectable BBHs form at different redshifts and metallicities, with detectable HMXBs forming at much lower redshifts and higher metallicities than detectable BBHs. We also find disparities in the mass distributions of these populations, with detectable merging BBH progenitors pulling to higher component masses relative to the full detectable HMXB population. Fewer than 3% of detectable HMXBs host BHs >35M_⊙in our simulated populations. Furthermore, we find the probability that a detectable HMXB will merge as a BBH system within a Hubble time is ≃0.6%. Thus, it is unsurprising that no currently observed HMXB is predicted to form a merging BBH with high probability.